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Faculty members and staff in the Department of Neurology at the University of Wisconsin are conducting basic and clinical research programs within the neurosciences.The department is committed to the translation of basic research findings to the clinical domain and actively encourages and facilitates interactions and collaborations between clinicians and basic scientists both within the department and in other departments and
schools.

Research activities are funded by government, foundation, private donor and industry sponsors.  Research programs are an integral part of the department's mission and play a central role in its activities. Basic science research is focused in computational neuroscience physical theory, epileptogenesis, neuropsychology, plasticity, biology of neural stem cells and embryonic stem cells and neural differentiation. 

Researchers & Labs
Funding / Grants
Clinical Trials
Publications
Corinna Burger, Ph.D.

Our lab is interested in two main problems in molecular neuroscience: the molecular biology of learning and memory, and the genetic mechanisms underlying neurodegenerative disorders. 

Dr. Burger's Lab

Qiang Chang, Ph.D.

Our long-term goal is to understand the molecular mechanism underlying DNA methylation-dependent epigenetic regulation of brain functions. Our current focus is on the central role of MeCP2 (methyl-CpG binding protein 2), a molecular linker between DNA methylation and chromatin remodeling and transcriptional control, in the development and function of the nervous system.

Dr. Chang's Research

Catherine Gallagher, M.D.

Dr. Gallagher’s research aims to develop new neuroimaging biomarkers for the pathology and progression of Parkinson’s disease. In particular, the lab is interested in how disease-related changes in brain connectivity affect cognition in Parkinson’s disease. Currently we are recruiting Parkinson’s and control subjects to participate in a longitudinal MRI study, and are preparing to analyze novel image sequences from the first time point. Data analyses will include looking for associations between standardized cognitive and motor evaluations and brain imaging parameters such as functional and structural connectivity, volumetric studies, and quantification of white matter hyperintensity volume.

Gallagher Lab

Bruce Hermann, Ph.D.

Our current research is focused in two areas:

  1. The effects of childhood onset epilepsies on brain structure, cognition and psychiatric status (3 NIH RO1 44351). This involves baseline cross-sectional and longitudinal (2, 5, 10 year) follow-up of the cohort. This research is carried out with our collaborators in medical physics, radiology, psychiatry, neurology and neuropsychology here at UW along with collaborators at other institutions.
  2. The effects of chronic epilepsy on brain and cognitive aging 

Dr. Hermann's Lab

David Hsu, M.D., Ph.D.

Brain function must manifest in the spatiotemporal patterns of neuronal activity.  What’s the secret?  How can we crack the code?  We discuss two properties of brain systems that may be key: the recent finding that neocortical slice cultures show what is called critical homeostasis, and the very old and well known finding that the intact brain shows oscillations.  Critical homeostasis addresses the spatial connectivity-related aspects of these patterns, while oscillations address the temporal patterns.  Disorders of critical homeostasis and abnormal oscillations may result in neurological disorders including epilepsy, mental retardation and movement disorders.

Dr. Hsu's Lab

Zhen Huang, Ph.D.

The cerebral cortex is the site of higher cognitive function in the brain. Its function depends critically on the intricate organization at several levels within the cortex. This ranges from the global organization of neuronal cell bodies in the cortex (e.g., the formation of cortical layers), to the elaboration of distinct dendritic patterns by various types of neurons, and eventually to the formation of specific synaptic connections among the different types of neurons. My lab is interested in several aspects of the development of the cerebral cortex. We are particularly interested in how these different levels of organization in the cerebral cortex arise during normal development and how they are affected in and contribute to human diseases. We are using several approaches including mouse genetics and in vitro tissue culture to address these questions.

Dr. Huang's Lab

Hrissanthi "Chris" Ikonomidou, M.D., Ph.D.

The goal of my research is to understand how the developing brain reacts to various insults and find ways to protect it. The knowledge gained may help optimize therapeutic interventions in infants born prematurely, infants and children with brain injuries, seizures, neurodevelopmental disorders or cancer.

Dr. Chris Ikonomidou's Lab

Robert Kotloski, M.D., Ph.D.

My laboratory studies the neurophysiologic, molecular, and cellular mechanisms underlying development of epilepsy (epileptogenesis) in an animal model, with a goal of identifying biomarkers and therapeutic targets.  Current efforts are focused on the development of epilepsy following a traumatic brain injury (post-traumatic epileptogenesis).

Robert Kotloski Lab

Christopher Luzzio, M.D.

Dr. Luzzio has an affiliate appointment in the Department of Mechanical Engineering and a grant to study methods of treating hydrocephalus.

Dr. Luzzio's Research

 

Rama Maganti, M.D.

Our current research is focused in two areas:

1. Understanding relationship between sleep and epilepsy, circadian distribution of seizures and clock genes

2. Understanding relationship between sleep, memory and synaptic plasticity in a developing brain

Rama Maganti Lab

Paul Rutecki, M.D.

The main goal of my laboratory is to understand the synaptic physiology of the hippocampus and how that circuitry favors epileptiform activity.

Dr. Rutecki's Lab

Aaron Struck, M.D.

Molecular Imaging in Epilepsy:
In collaboration with the Department of Medical Physics and Radiology we use novel radiotracers and PET imaging to explore the underlying causes of epilepsy with the goal of developing new avenues for treatment. Studies underway include agents targeting tau and inflammation.
 
Continuous EEG in Patients with Critical Illness:
We are finding ways to optimize the care of patients with critical neurologic illness through the better use and interpretation of continuous EEG monitoring.
 
Automated Natural Language Interpretation of EEG:
We seek methods to expand the application and reliability of EEG using machine learning techniques to automate several aspects of EEG interpretation.

Aaron Struck's Lab

Thomas Sutula, M.D., Ph.D.

Our group studies activity-dependent circuit plasticity in the developing and adult hippocampus, a region of brain that plays a role in learning, memory, and epilepsy

Dr. Sutula's Lab

Cara Westmark, Ph.D

Dr. Westmark’s basic and translational science research in the fields of Alzheimer’s disease and fragile X syndrome focuses on the synaptic function of amyloid beta protein precursor (APP) and amyloid-beta. The goal is to identify therapeutic and dietary approaches that reduce amyloid-beta and rescue seizure, behavioral, cognitive and biomarker phenotypes.

Cara Westmark's Lab

Jerry C P Yin, Ph.D.

The goal of my research is to understand nervous system function during complex behavior at the molecular level.

Jerry Yin's Genetics Lab

Su-Chun Zhang, M.D., Ph.D.

Our lab focuses on how human neuroepithelial cells are specified and subsequently differentiated into neurons and glia.

Dr. Zhang's Lab