Innate immune activation during acute and chronic focal cerebral ischemia:
The Famakin Lab is investigating the innate immune response to acute and chronic focal cerebral ischemia. Specifically, we are interested in identifying the temporal and cellular specificity of innate immune pathways activated during the acute and chronic phases of focal cerebral ischemia. We use the Middle Cerebral Artery occlusion model, in rodents, as a model of experimental focal cerebral ischemia. We also use in vitro models of cerebral ischemia to confirm the involvement, and identify key control points, in important pathways activated during acute and chronic focal cerebral ischemia. We are also interested in the role of the innate immune response in modulating repair and recovery during chronic stroke. Some of the other tools we employ in our research include fluorescent imaging and various molecular biology techniques. The goal of these studies is to obtain foundational knowledge needed to develop novel therapeutic targets, or re-purpose old drugs, that can ameliorate damaging inflammation during the acute phase and potentiate repair during the chronic reparative phase of stroke.
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