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Famakin Lab

Famakin Lab

Bolanle Famakin, M.D.
Bolanle Famakin, M.D.

Innate immune activation during acute and chronic focal cerebral ischemia:

The Famakin Lab is investigating the innate immune response to acute and chronic focal cerebral ischemia. Specifically, we are interested in identifying the temporal and cellular specificity of innate immune pathways activated during the acute and chronic phases of focal cerebral ischemia. We use the Middle Cerebral Artery occlusion model, in rodents, as a model of experimental focal cerebral ischemia. We also use in vitro models of cerebral ischemia to confirm the involvement, and identify key control points, in important pathways activated during acute and chronic focal cerebral ischemia. We are also interested in the role of the innate immune response in modulating repair and recovery during chronic stroke. Some of the other tools we employ in our research include fluorescent imaging and various molecular biology techniques. The goal of these studies is to obtain foundational knowledge needed to develop novel therapeutic targets, or re-purpose old drugs, that can ameliorate damaging inflammation during the acute phase and potentiate repair during the chronic reparative phase of stroke.

Toll-Like Receptor 4 Signaling in Focal Cerebral Ischemia: a Focus on the Neurovascular Unit
Famakin BM, Vemuganti R.
Mol Neurobiol. 2020 Jun;57(6):2690-2701. doi: 10.1007/s12035-020-01906-5. Epub 2020 Apr 18.
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HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia
Famakin BM, Tsymbalyuk O, Tsymbalyuk N, Ivanova S, Woo SK, Kwon MS, Gerzanich V, Simard JM.
Neurol Res Int. 2020 Feb 20;2020:3929438. doi: 10.1155/2020/3929438. eCollection 2020.
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Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial
Johnston KC, Bruno A, Pauls Q, Hall CE, Barrett KM, Barsan W, Fansler A, Van de Bruinhorst K, Janis S, Durkalski-Mauldin VL; Neurological Emergencies Treatment Trials Network and the SHINE Trial Investigators.
JAMA. 2019 Jul 23;322(4):326-335. doi: 10.1001/jama.2019.9346.
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Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts
Mehta RI, Tosun C, Ivanova S, Tsymbalyuk N, Famakin BM, Kwon MS, Castellani RJ, Gerzanich V, Simard JM.
J Neuropathol Exp Neurol. 2015 Aug;74(8):835-49. doi: 10.1097/NEN.0000000000000223.
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The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review
Famakin BM.
Aging Dis. 2014 Oct 1;5(5):307-26. doi: 10.14336/AD.2014.0500307. eCollection 2014 Oct.
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A new role for downstream Toll-like receptor signaling in mediating immediate early gene expression during focal cerebral ischemia
Famakin BM, Mou Y, Johnson K, Spatz M, Hallenbeck J.
J Cereb Blood Flow Metab. 2014 Feb;34(2):258-67. doi: 10.1038/jcbfm.2013.182. Epub 2013 Dec 4.
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Combined approach to lysis utilizing eptifibatide and recombinant tissue plasminogen activator in acute ischemic stroke-enhanced regimen stroke trial
Pancioli AM, Adeoye O, Schmit PA, Khoury J, Levine SR, Tomsick TA, Sucharew H, Brooks CE, Crocco TJ, Gutmann L, Hemmen TM, Kasner SE, Kleindorfer D, Knight WA, Martini S, McKinney JS, Meurer WJ, Meyer BC, Schneider A, Scott PA, Starkman S, Warach S, Broderick JP; CLEAR-ER Investigators.
Stroke. 2013 Sep;44(9):2381-7. doi: 10.1161/STROKEAHA.113.001059. Epub 2013 Jul 25.
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Downstream Toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia
Famakin B, Mou Y, Spatz M, Lawal M, Hallenbeck J.
J Neuroinflammation. 2012 Jul 16;9:174. doi: 10.1186/1742-2094-9-174.
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Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia
Famakin BM, Mou Y, Ruetzler CA, Bembry J, Maric D, Hallenbeck JM.
Brain Res. 2011 May 4;1388:148-56. doi: 10.1016/j.brainres.2011.02.074. Epub 2011 Mar 1.
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Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry
Famakin B, Weiss P, Hertzberg V, McClellan W, Presley R, Krompf K, Karp H, Frankel MR.
J Stroke Cerebrovasc Dis. 2010 Jan;19(1):17-22. doi: 10.1016/j.jstrokecerebrovasdis.2009.01.015.
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No Grant Information Found

Lab Staff

Sireesh Teertam

Position title: Research Associate

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