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Funding & Grants

The Juvenile Myoclonic Epilepsy Connectome Project
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R01NS111022-01A1
PI: STRUCK, AARON F
3/15/2020 - 1/31/2026
Preparing for preventive clinical trials in Huntington's disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 7U01NS105509-03
PI: PAULSEN, JANE S
4/23/2020 - 1/31/2025
NAD+ metabolism and signaling in ALS models
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 2R01NS089640-07
PI: VARGAS, MARCELO R
9/30/2020 - 8/31/2025
Electroencephalography and single-unit recordings
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1K23NS112473-01A1
PI: BOLY, MELANIE
12/15/2020 - 11/30/2025
Role of FABP7 in ALS models
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R01NS122973-01
PI: VARGAS, MARCELO R
7/1/2021 - 4/30/2026
Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1RF1AG074608-01
PI: Paulsen,Jane S
09/30/2021 - 08/31/2025
Brain Aging and Cognition in Epilepsy
Sponsor: UNIVERSITY OF CALIFORNIA - SAN DIEGO
Award: KR 704829
PI: Jones,Jana E
09/01/2021 - 02/28/2026
Preclinical Testing of the Effects of Diet and FMRP on Gut and Brain Barrier Integrity in a Mouse Model of Fragile X
Sponsor: DOD, ARMY
Award: HT94252310076
PI: Westmark,Cara J
01/15/2023 - 01/14/2026
Astrocyte-specific TLR4 signaling and Blood Brain Barrier permeability following acute focal cerebral ischemia
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1K08NS130144-01
PI: Famakin, Bolanle
3/1/2023 - 2/29/2028
Astrocyte-specific TLR4 signaling and Blood Brain Barrier permeability following acute focal cerebral ischemia
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1K08NS130144-01
PI: Famakin,Bolanle M;
03/01/2023 - 02/29/2028
Dual Orexin Antagonist Treatment to Prevent the Neurobehavioral Sequelae of TBI
Sponsor: DOD, ARMY
Award: HT9425-23-1-0200
PI: Maganti,Rama Krishna
04/01/2023 - 03/31/2027
Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain Injury
Sponsor: BETH ISRAEL DEACONESS MEDICAL CENTER
Award: GRT65212
PI: Struck,Aaron F;
01/01/2027 - 12/31/2027
Harnessing a novel Ab40 anti-inflammatory pathway for AD intervention
Sponsor: ICTR Pilot Funds
Award: ICTR-UWHC RD 14
PI: HUANG, ZHEN
09/01/2020 - 01/31/2022
Linking altered sleep homeostasis to increased autonomic instability and SUDEP risk in patients with epilepsy
Sponsor: Lily's Grace Grant
Award: 9/1/2021
PI: BOLY, MELANIE
07/01/2020 - 06/30/2022
Modeling Pathogenicity and Treatment Response in Epileptic Channelopathies
Sponsor: Lily's Grace Grant
Award: 6/4/2021
PI: KNOX, ANDREW T
07/01/2021 - 06/30/2023
Acute Inflammation from Focal Seizures using [18F]-FEPPA PET/MR
Sponsor: Lily's Grace Grant
Award: 5/30/2019
PI: STRUCK, AARON F
07/01/2019 - 06/30/2022
Pilot Study investigating the role of FAPI in glioma
Sponsor: Radiology R&D/SOFIE Pharma
Award:
PI:
-
Phase 3 Study randomizing patients to IV Berubicin vs PO Lomustine in 1st recurrent GBM
Sponsor: Worldwide pharmaceuticals
Award:
PI: Bhatia, Ankush
-
Phase 2 Study combining temozolomide with lomustine in MGMT Methylated GBM
Sponsor: NRG Oncology (Cooperative Group)
Award:
PI: Bhatia, Ankush
-
Phase 2 study combining Bevacizumab with Pulsed Reduced Dose Rate Radiotherapy in recurrent GBM
Sponsor: Merck
Award:
PI: Bhatia, Ankush
-
A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma
Sponsor: Imvax
Award:
PI: Bhatia, Ankush
-
Mapping Synaptic Density in Prodromal and Manifest Lewy Body Dementia
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R01AG082174-01A1
PI: GALLAGHER, CATHERINE L
09/25/2024 - 07/31/2029
MDA Care Center at American Family Children's Hospital
Sponsor: MUSCULAR DYSTROPHY ASSOCIATION, INC
Award: 492461
PI: KWON, JENNIFER
01/01/2019 - 06/30/2025
A Prospective, Long Term Registry of Patients with a Diagnosis of Spinal Muscular Atrophy
Sponsor: NOVARTIS
Award: AVXS-101-RG-001
PI: KWON, JENNIFER
07/26/2018 - 12/31/2099
An Open-label, Single Arm, Multi-center Extension Study Evaluating Long-term Safety, Tolerability and Effectiveness of Ofatumumab in Subjects with Relapsing Multiple Sclerosis
Sponsor: NOVARTIS
Award: OMB157G2399 ATHIOS COMB
PI: Luzzio,Christopher C;
08/24/2018 - 12/31/2099
New-Onset Refractory Status Epilepticus (NORSE)
Sponsor: YALE UNIVERSITY
Award: NORSE
PI: Struck,Aaron F;
02/05/2019 - 12/31/2099
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of K0706 in Subjects With Early Parkinson's Disease
Sponsor: SUN PHARMA ADVANCED RESEARCH COMPANY LTD
Award: CLR_18_06
PI: Shannon,Kathleen M;
09/11/2019 - 12/31/2040
A Long-term Follow-up Study of Patients in the Clinical Trials for Spinal Muscular Atrophy Receiving AVXS-101
Sponsor: NOVARTIS
Award: AVXS-101-LT-002
PI: KWON,JENNIFER
03/12/2020 - 12/31/2040
A multicenter, randomized, active-controlled, double-blind, double-dummy, parallel group clinical trial, investigating the efficacy, safety, and tolerability of continuous subcutaneous ND0612 infusion in comparison to oral IR-LD/CD
Sponsor: NEURODERM LTD
Award: ND0612-317
PI: Buyan Dent,Laura;
03/12/2020 - 12/31/2040
Trial Of Parkinson’s And Zoledronic acid (TOPAZ)
Sponsor: PARKINSON'S FOUNDATION
Award:
PI: Shannon,Kathleen M;
07/09/2020 - 02/01/2026
A multicenter, longitudinal, open-label, single-arm study describing cognitive processing speed changes in relapsing multiple sclerosis subjects treated with Ozanimod
Sponsor: CELGENE CORPORATION
Award: RPC-1063-MS-001
PI: Frost,Natasha;
05/12/2021 - 12/31/2040
Seizure Assessment and Forecasting with Efficient Rapid-EEG: A Retrospective Comparative Effectiveness Trial
Sponsor: CERIBELL
Award: rapid2HELPS2B
PI: Struck,Aaron F;
08/12/2021 - 12/31/2099
A double blind, randomized, placebo controlled, parallel group trial of the efficacy and safety of Sativex oromucosal spray (Sativex?; nabiximols), as add on therapy in patients with spasticity due to multiple sclerosis
Sponsor: GW PHARMACEUTICALS
Award: GWSP18023
PI: Luzzio,Christopher C;
10/14/2021 - 12/31/2099
An Intermediate size, Expanded Access Protocol to Provide AMX0035, a Fixed Combination of Sodium Phenylbutyrate (PB) and Taurursodiol (TURSO)
Sponsor: AMYLYX PHARMACEUTICALS INC
Award: AMX0035
PI: Gardon,Stephanie;
03/18/2022 - 12/31/2040
Muscular Dystrophy Association Neuromuscular Observational Research (MOVR) Data Hub Protocol
Sponsor: MUSCULAR DYSTROPHY ASSOCIATION, INC
Award: MOVR Registry
PI: Kwon,Jennifer Meesuk; Gardon,Stephanie;
10/07/2021 - 12/31/2040
Phase 3, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Apitegromab (SRK-015) in Patients with Later-Onset Spinal Muscular Atrophy
Sponsor: SCHOLAR ROCK
Award: SRK-015-003
PI: Kwon,Jennifer Meesuk;
05/25/2022 - 12/31/2040
ENROLL-HD A Prospective Registry Study in a Global Huntington's Disease Cohort
Sponsor: CHDI FOUNDATION
Award: ENROLL-HD A-16004
PI: Shannon,Kathleen M;
03/27/2021 - 12/31/2099
MDA Care Center at American Family Children's Hospital
Sponsor: MUSCULAR DYSTROPHY ASSOCIATION, INC
Award: 492461
PI: Kwon,Jennifer Meesuk;
07/01/2022 - 06/30/2025
Identifying the neural mechanisms of loss of consciousness during sleep using intracranial recordings in humans
Sponsor: TEMPLETON WORLD CHARITY FDN
Award: TWCF-2022-30258
PI: Boly,Melanie;
01/01/2023 - 12/31/2025
Accelerating research on consciousness
Sponsor: UNIVERSITEIT VAN AMSTERDAM
Award: C2328.0527 TWCF0646
PI: Boly,Melanie;
03/01/2022 - 10/01/2026
A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus
Sponsor: MARINUS PHARMACEUTICALS
Award: 1042-SE-3003
PI: Struck,Aaron F;
06/08/2022 - 12/31/2040
A Randomized, Double-Blind, Placebo-Controlled Trial of IkT-148009 in Untreated Parkinson's Disease
Sponsor: IQVIA RDS
Award: IkT-148009-201
PI: Shannon,Kathleen M;
10/11/2022 - 12/31/2040
Phase 3, multicenter, randomized, double-blind, group sequential, placebo-controlled study to assess efficacy and safety of rimegepant for the treatment of migraine (with or without aura) in children and adolescents ≥ 6 to < 18 years of age
Sponsor: BIOHAVEN PHARMACEUTICALS
Award: BHV3000-311
PI: Zandieh,Ali;
11/28/2022 - 12/31/2099
Phase 3, multicenter, open-label study to assess the long-term safety and tolerability of Rimegepant for the acute treatment of migraine (with or without aura) in children and adolescents ≥ 6 to < 18 years of age
Sponsor: BIOHAVEN PHARMACEUTICALS
Award: BHV3000-312
PI: Zandieh,Ali;
01/05/2023 - 12/31/2099
A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib
Sponsor: NOVARTIS PHARMACEUTICALS KK
Award: LOU064C12301
PI: Frost,Natasha;
12/12/2022 - 12/31/2040
Predictors of Cognitive Disability and Executive Dysfunction After Acute Symptomatic Neonatal Seizures
Sponsor: THRASHER RESEARCH FUND
Award: 01841
PI: Carrasco Mccaul,Melisa;
01/01/2023 - 06/30/2025
Novartis Pharmaceuticals - US - COAV101B12302, Phase IIIb, open-label, single-arm, multi-center study to evaluate the safety, tolerability and efficacy of OAV101 administered intrathecally (1.2 x 1014 vector genomes) to participants 2 to 12 years of age
Sponsor: NOVARTIS PHARMACEUTICALS KK
Award: COAV101B12302
PI: Kwon,Jennifer Meesuk;
01/01/2023 - 12/31/2040
A study to evaluate the effects of SAGE-718 in participants with Parkinson's Disease cognitive impairment
Sponsor: SAGE THERAPEUTICS INC
Award: Sage PD 715-CNP-202 CTA
PI: Shannon,Kathleen M;
05/10/2023 - 12/31/2040
A Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants with Huntington's Disease
Sponsor: PAREXEL INTERNATIONAL CORPORATION
Award: Sage HD 718 CTA
PI: Shannon,Kathleen M;
04/21/2023 - 12/31/2040
A 2-Part, Multicenter, Randomized, Blinded, Active-Controlled Phase 2 Study to Sequentially Evaluate the Safety and Efficacy of BIIB091 Monotherapy and BIIB091 Combination Therapy With Diroximel Fumarate in Participants With Relapsing Forms of MS
Sponsor: BIOGEN IDEC
Award: AGR00000302
PI: Luzzio,Christopher C;
09/14/2023 - 12/31/2099
Whole Genome Sequencing Study of CMT patients and their families
Sponsor: VANDA PHARMACEUTICALS INC.
Award: MSN278949
PI: Kwon,Jennifer Meesuk;
11/29/2023 - 12/31/2099
Development of a disease-specific clinical rating scale for the late-onset GM2 gangliosidoses (Tay-Sachs and Sandhoff) (Julie Kissell is the grad student/ PI)
Sponsor: NTL TAY-SACHS & ALLIED DISEASES ASSOC
Award: MSN277277
PI: Kwon,Jennifer Meesuk;
01/04/2024 - 01/03/2026
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel, Multicenter Study to Evaluate the Safety and Efficacy of ALXN1720 in Adults with Generalized Myasthenia Gravis
Sponsor: ALEXION PHARMACEUTICALS, INC
Award: ALXN1720-MG-301
PI: Gardon,Stephanie;
02/08/2024 - 12/31/2099
An Open-Label, Multicenter, Extension Trial to Evaluate the Long-Term Safety and Efficacy of Apitegromab in Patients with Type 2 and Type 3 Spinal Muscular Atrophy Who Completed Previous Investigational Trials of Apitegromab
Sponsor: SCHOLAR ROCK
Award: SRK-015-004
PI: Kwon,Jennifer Meesuk;
03/13/2024 - 12/31/2099
Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVER-MS)
Sponsor: CLEVELAND CLINIC FOUNDATION
Award: CCF24454739 LTE DELIVER MS
PI: Frost,Natasha;
07/01/2023 - 06/30/2026
A Phase 2 study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and potential efficacy of multiple doses of ONO-2808 in patients with MSA
Sponsor: ONO PHARMACEUTICAL CO LTD
Award: ONO-2808-03
PI: Shannon,Kathleen M;
07/03/2024 - 12/31/2099
A Phase 2, Randomized, Double-blind, Sham Surgery-controlled Study of the Efficacy and Safety of Intraputaminal AAV2-GDNF in the Treatment of Adults with Moderate Stage Parkinson?s Disease
Sponsor: ASKLEPIOS BIOPHARMACEUTICAL INC
Award: ASK-PD5-CS201
PI: Shannon,Kathleen M;
08/09/2024 - 12/31/2099
Long-term follow-up of patients with spinal muscular atrophy treated with OAV101 IT or OAV101 IV in Clinical Trials
Sponsor: NOVARTIS PHARMACEUTICALS KK
Award: OAV101A12308 3605
PI: Kwon,Jennifer Meesuk;
08/01/2024 - 08/31/2039
Understanding the Role of Play Quality in Cognitive Outcomes for Children with CP-PBI
Sponsor: CAPLAN FOUNDATION FOR EARLY CHILDHOOD
Award: 24-0040WI
PI: Carrasco Mccaul,Melisa;
09/01/2024 - 08/31/2026
The treatment of Charcot-Marie-Tooth disease, axonal, type 2S (CMT2S) in an individual patient with confirmed IGHMBP2 intronic cryptic splice variant c.1235+894C>A that is amenable to antisense oligonucleotide (ASO)-mediated correction of IGHMBP2 slicing
Sponsor: VANDA PHARMACEUTICALS INC.
Award: VP-VCA-894A-2101
PI: Kwon,Jennifer Meesuk;
02/12/2025 - 12/31/2099
Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis
Sponsor: CLEVELAND CLINIC FOUNDATION (PCORI prime sponsor)
Award: MS-1610-37047
PI: FROST, NATASHA
2/1/2018 - 12/01/2026
In vivo Imaging of Glymphatic Circulation: Measurement of Brain Interstitial Fluid Flow During Wake and Sleep with Ultra-High Performance MRI
Sponsor: GE GLOBAL RESEARCH
Award: 401180352
PI: Boly,Melanie;
08/15/2022 - 08/14/2025
Development of Lovastatin or Related Compounds as a Therapy for ALS
Sponsor: WASHINGTON UNIVERSITY
Award: WU-24-0044
PI: Kreple,Collin John;
07/01/2023 - 06/30/2025
Quantitative Ultrasound Imaging of the Neonatal Brain
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R21HD114041-01
PI: Ikonomidou,Hrissanthi;
08/01/2024 - 07/31/2026
A Mouse Model for Braak I/II Alzheimer's Pathology
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R21AG085588-01A1
PI: Huang,Zhen;
09/15/2024 - 05/31/2026
Retinal biomarkers in monogenic vascular cognitive impairment and dementia
Sponsor: DHHS, PHS, FOOD AND DRUG ADMINISTRATION
Award: 1U01FD008399-01
PI: Paulsen,Jane S;
09/05/2024 - 08/31/2028
A Second Intermediate-Size Expanded Access Protocol for Pridopidine in People with Amyotrophic Lateral Sclerosis
Sponsor: MASSACHUSETTS GENERAL HOSPITAL
Award: AGR00005333
PI: Kreple,Collin John;
09/18/2024 - 08/31/2027
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Sponsor: MASSACHUSETTS GENERAL HOSPITAL
Award: 246047
PI: Boly,Melanie;
08/01/2024 - 05/31/2025
Effects of Noninvasive Brain Stimulation on the Developing Brain
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R21NS136909-01A1
PI: Ikonomidou,Hrissanthi;
12/15/2024 - 11/30/2026