ABOUT THE LAB
The Paulsen Lab researches the early biomarkers of rare neurological disease, with a focus on Huntington’s Disease and CADASIL. The Lab conducts observational or natural history studies and investigates the clinical, imaging, biofluid, and genetic features of these diseases in order to benefit the eventual development of therapeutic interventions.
RESEARCH PROJECTS
TEAM
Jane Paulsen
Credentials: Ph.D.
Position title: Professor
Education
Doctorate:
University of Iowa
Post doctorate:
University of California, San Diego
Research Interests
Cognitive, psychiatric and imaging correlates of neuropsychiatric disorders; early detection of brain disease; methods development for clinical trials, genetic discrimination, discovery and validation of biological and clinical markers of brain disease; neuroimaging; omics markers as clinical trial outcomes.
Researcher Profile
| Title: Statistical disease modeling and clinimetrics to prepare for preventive trials in Huntington’s disease Project Number: 7U01NS103475-04 Name of PD/PI: Jane Paulsen Source of Support: DHHS, NIH, NINDS Project/Proposal Start and End Date: 04/23/2020–03/31/2025 |
| Title: Preparing for preventive clinical trials in Huntington’s disease Project Number: 7U01NS105509-03 Name of PD/PI: Jane Paulsen Source of Support: DHHS, NIH, NINDS Project/Proposal Start and End Date: 04/23/2020–01/31/2026 |
| Title: Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL–a monogenic form of small vessel cerebrovascular disease Project Number: 1RF1AG074608-01 Name of PD/PI: Jane Paulsen, Michael Geschwind Source of Support: DHHS, NIH, NIA Project/Proposal Start and End Date: 09/30/2021–08/31/2025 |
| Title: Non-Invasive MRI Markers to Elicit the Role of Vascular Disease in CADASIL Compared to Normal Aging Project Number: 1R01AG082208-01A1 Name of PD/PI: Laura Eisenmenger, Jane Paulsen Source of Support: DHHS, NIH, NIA Project/Proposal Start and End Date: 02/01/2024–01/31/2029 |
| Title: Cerebrovascular reactivity as a VCID Biomarker in CADASIL Project Number: 1R01AG085602-01A1 Name of PD/PI: Jill Barnes, Jane Paulsen, Hanzhang Lu Source of Support: DHHS, NIH, NIA Project/Proposal Start and End Date: 09/01/2024–08/31/2029 |
| Title: Retinal biomarkers in monogenic vascular cognitive impairment and dementia Project Number: U01FD008399-01 Name of PD/PI: Jane Paulsen Source of Support: DHHS, FDA Project/Proposal Start and End Date: 09/05/2024 – 08/31/2028 |
| Liu, C.F., Younes, L., Tong, X.J., Hinkle, J.T., Wang, M., Phatak, S., Xu, X., Bu, X., Looi, V., Bang, J., Tabrizi, S.J., Scahill, R.I., Paulsen, J.S., … & Ross, C.A. (2023) Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington’s disease. Brain Communication, 5(5), fcad214. doi: 10.1093/braincomms/fcad214. Epub 2023 Aug 18. PMID: 37744022. PMCID: PMC10516592. |
| Eisenmenger, L.B., Peret, A., Famakin, B.M., Spahic, A., Roberts, G.S., Bockholt, H.J., Johnson, K.M. & Paulsen, J.S. (2023). Vascular Contributions to Alzheimer’s Disease. Translational Research, 254, 41-53. doi: 10.1016/j.trsl.2022.12.003. Epub 2022 Dec 15. PMID: 36529160. PMCID: PMC10481451. |
| Sokol, L., Nance, M., Kluger, B.M., Yeh, C., Paulsen, J.S., Smith, A.K. & Bega, D. (2023). Factors Associated with the Place of Death in Huntington Disease: Analysis of Enroll-HD. Journal of Palliative Medicine, 26(7), 915-921. doi: 10.1089/jpm.2022.0143. Epub 2023 Jan 27. PMID: 36706436. PMCID: PMC10316529. |
| Sokol, L., Troost, J.P., Bega, D., Paulsen, J.S., Kluger, B.M., Applebaum, A.J., … & Carlozzi, N.E. (2023). Death Anxiety in Huntington disease: Longitudinal Health-Related Quality of Life (HRQoL) Outcomes. Journal of Palliative Medicine, 26(7), 907-914. doi: 10.1089/jpm.2022.0160. Epub 2023 Jan 6. PMID: 36607769. PMCID: PMC10316526. |
| Stoebner, Z.A., Hett, K., Lyu, I., Johnson, H., Paulsen, J.S., Long, J.D. & Oguz, I. (2023). Comprehensive shape analysis of the cortex in Huntington’s disease. Human Brain Mapping, 44(4), 1417-1431. doi: 10.1002/hbm.26125. Epub 2022 Nov 21. PMID: 36409662. PMCID: PMC9921229. |
| Wijeratne, P.A., Eshaghi, A., Scotton, W.J., Kohli, M., Aksman, L., Oxtoby, N.P., Pustina, D., Warner, J.H., Paulsen, J.S., … & Alexander, D.C. (2023). The temporal event-based model: Learning event timelines in progressive diseases. Imaging Neuroscience, 1(1), 1-19. doi: 10.1162/imag_a_00010. Epub 2023 Aug 21. PMID: 37719837. PMCID: PMC10503481. |
| Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium, Lee, J.-M., McLean, Z.L., Correia, K., Shin, J.W., Lee, S., Jang, J.-H., Lee, Y., Kim, K.-H., Choi, D.E., Long, J.D., Lucente, D., Seong, I.S., Pinto, R.M., Giordano, J.V., Mysore, J.S., Jacqueline, S., Elezi, E., Ruliera, J., Gillis, T., Wheeler, V.C., MacDonald, M.E., Gusella, J.F., Gatseva, A., Ciosi, M., Lomeikaite, V., Loay, H., Monckton, D.G., Wills, C., Massey, T.H., Jones, L., Holmans, P., Kwak, S., Sampaio, C., Orth, M., Landwehrmeyer, B., Paulsen, J.S., … & Myers, R.H. (2024). Genetic modifiers of somatic expansion and clinical phenotypes in Huntington’s disease reveal shared and tissue-specific effects. doi: 10.1101/2024.06.10.597797. PMID: 38948755. |
| Ghofrani-Jahromi, M., Poudel, G.R., Razi, A., Abeyasinghe, P.M., Paulsen, J.S., Tabrizi, S.J., … & Georgiou-Karistianis, N. (2024). Prognostic enrichment for early-stage Huntington’s disease: An explainable machine learning approach for clinical trial. NeuroImage: Clinical, 43, 103650. doi: 10.1016/j.nicl.2024.103650. Epub 2024 Aug 10. PMID: 39142216. PMCID: PMC11367643. |
| Paulsen, J.S. & Gehl, C. (2024). Clinical Neuropsychology: Integration and Application in Neurology. Neurologic Clinics, 42(4), xii-xiv. doi: 10.1016/j.ncl.2024.06.001. Epub 2024 Jul 25. PMID: 39343488. |
| Cavanagh, L. & Paulsen, J.S. (2024). Neuropsychology and Vascular Cognitive Impairment and Dementia. Neurologic Clinics, 42(4), 809-820. doi: 10.1016/j.ncl.2024.05.006. Epub 2024 Jun 29. PMID: 39343476. |
Oral presentations:
| Paulsen, J.S. (2023). Progress in Biomarkers for Huntington’s Disease. National Academies of Science, Forum on Neuroscience and Nervous System Disorders, Multimodal Biomarkers for Central Nervous Systems Disorders, Washington, DC. March. |
| Paulsen, J.S. (2023). The US CADASIL Consortium: A Multi-site Natural History Study. United Leukodystrophy Family Conference. Itasca, IL. June. |
| Paulsen, J.S. (2023). From gene mutation to disease prevention: Progress and challenges in the HD continuum. 148th Annual Meeting of the American Neurological Association, Philadelphia, PA. September. |
| Paulsen, J.S. (2024). Family Participation: The Key to Success in Genetic Research. cureCADASIL. Virtual. January. |
| Paulsen, J.S., Baker, B.T., Fornage, M., Ferrante, E., Bockholt, H.J. & Biller, J. (2024). Symposium: Biomarkers for Cerebrovascular Contributions to Neurodegeneration: Genetic, Biofluid, and Imaging. Neuroscience 2024. Chicago, IL. October. |
Poster presentations:
| Bockholt, H.J., Baker, B.T., Joyce, C., Adams, W.H., Clemsen, J., Pasley, N., … & Paulsen, J.S. (2024). Data Fusion in Huntington’s Disease Research: A Holistic Approach to Neuroimaging Biomarkers. International Conference on Alzheimer’s Disease and Parkinson’s Diseases and Related Neurological Disorders. Lisbon, Portugal. March. |
| Bockholt, H.J., Baker, B.T., Pasley, N., Clemsen, J., Eisenmenger, L., Liebeskind, D.S., Geschwind, M.D., Calhoun, Vince D. & Paulsen, J.S. (2024). Quantitative Analysis of White Matter Neuroimaging Biomarkers in a US CADASIL Consortium. International Conference on Alzheimer’s Disease and Parkinson’s Diseases and Related Neurological Disorders. Lisbon, Portugal. March. |
| Bockholt, H.J., Clemsen, J., Chelsky, D., Joyce, C., Adams, W.H., Newton, M.A., … & Paulsen, J.S. (2024). Biofluid and Neuroimaging Markers in Prodromal Huntington’s Disease May Reveal A Multi-Modal Biomarker for Timing of Disease Prevention. International Conference on Alzheimer’s Disease and Parkinson’s Diseases and Related Neurological Disorders. Lisbon, Portugal. March. |
| Geschwind, M.D., Biller, J., Elliott, J.L., Jayadev, S., Salloway, S., Gutierrez, J., Seshadri, S., Majersik, J.J., Orjuela, K.D., Liebeskind, D.S., Lutsep, H.L., Hajjar, I., Elahi, F.M., Bockholt, H.J. & Paulsen, J.S. (2024). Unraveling the earliest phases of vascular cognitive impairment and dementia by establishing a large USA CADASIL Consortium. American Academy of Neurology 76th Annual Meeting 2024. Denver, CO. April. |
| Geschwind, M.D., Zitser-Koren, J., Elahi, F., Hajjar, I., Gutierrez, J., Fathali, I., Crossland, D., Terranova, M., Driscoll, T., Bockholt, H.J., Paulsen, J.S., Djakovic, M., Schneck, M.J. & Biller, J. (2024). Retrospective Study of Multi-Site CADASIL: Implications for Clinical and Research Practice. American Academy of Neurology 76th Annual Meeting 2024. Denver, CO. April. |
| Paulsen, J.S., Pinto, A., Bovin, N., Rudrud, M., Mahalingam, E., Janz, M. … & Shannon, K.M. (2024). How Robust Are Biomarkers for the Huntington Disease Continuum? American Academy of Neurology 76th Annual Meeting 2024. Denver, CO. April. |
| Bockholt, H.J., Baker, B.T., Eisenmenger, L.B., Geschwind, M.D., Liebeskind, D.S., Krishnamurthy, L. & Paulsen. J.S. (2024). Comprehensive MRI Anomaly Detection Interface for CADASIL and VCID: A Multimodal Approach. Organization for Human Brain Mapping 2024 Annual Meeting. Seoul, Korea. June. |
| Bockholt, H.J., Baker, B.T., Clemsen, J., Calhoun, V.D. & Paulsen, J.S. (2024). A Resting-State fMRI Study of Suicide Ideation Correlates in Huntington’s Disease. Organization for Human Brain Mapping 2024 Annual Meeting. Seoul, Korea. June. |
| Bockholt, H.J., Baker, B.T., Eisenmenger, L.B., Geschwind, M.D., Liebeskind, D.S., Krishnamurthy, L. & Paulsen. J.S. (2024). Comprehensive MRI Anomaly Detection Interface for CADASIL and VCID: A Multimodal Approach. Organization for Human Brain Mapping 2024 Annual Meeting. Seoul, Korea. June. |
| Bockholt, H.J., Baker, B.T., Caprihan, A., Johnson, K.M., Geschwind, M.D., Eisenmenger, L.B., Liebeskind, D.S., Clemsen, J., Adams, W.H., Newton, M.A., Calhoun, V.D., & Paulsen, J.S. (2024). Dynamic and static functional network connectivity distinguish symptomatic and non-symptomatic individuals with CADASIL. Alzheimer’s Association International Conference 2024. Philadelphia, PA. July. |
| Paulsen, J.S., Jayadev, S., Geschwind, M.D., Biller, J., Elliott, J.L., Gutierrez, J., Seshadri, S., Majersik, J.J., Orjuela, K.D., Liebeskind, D.S., Lutsep, H.L., Bockholt, H.J. & Salloway, S. (2024). Unraveling the earliest phases of vascular cognitive impairment and dementia by establishing a large USA CADASIL Consortium. Alzheimer’s Association International Conference 2024. Philadelphia, PA. July. |
| Orjuela, K.D., Jayadev, S., Geschwind, M.D., Biller, J., Elliott, J.L., Gutierrez, J., Seshadri, S., Majersik, J.J., Paulsen, J.S., Liebeskind, D.S., Lutsep, H.L., Bockholt, H.J. & Salloway, S. (2024). Paving the Way for Global Collaborative Research in CADASIL: A Comprehensive Multi-site U.S. Cohort Study. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September. |
| Janz, M.L., Adams, W.H., Key, A.M., Burks, D.K., Shannon, K.M. & Paulsen, J.S. (2024). Investigating Interrater Reliability of the Unified Huntington’s Disease Rating Scale Motor Component Between Learner and Experienced Rater. International Parkinson and Movement Disorder Society 2024 Congress. Philadelphia, PA. September. |
| Baker, B.T., Clemsen, J.D., Johnson, H., Paulsen, J.S. & Bockholt, H.J. (2024). Cross-sectional analysis of cerebral white matter parcellation in Huntington’s disease using 3T MRI scans with FreeSurfer. Neuroscience 2024. Chicago, IL. October. |
| Bockholt, H.J, Key, A.M., Clemsen, J.D., Baker, B.T., Rudrud, M.S., Johnson, H. & Paulsen, J.S. (2024). Cross-sectional analysis of cortical changes in Huntington’s disease using 3T MRI. Neuroscience 2024. Chicago, IL. October. |
| Clemsen, J.D., Key, A.M., Rudrud, M.S., Baker, B.T., Johnson, H., Paulsen, J.S. & Bockholt, H.J. (2024). Cross-sectional analysis of white matter integrity in Huntington’s disease using 3T diffusion tensor imaging. Neuroscience 2024. Chicago, IL. October. |
| Paulsen, J.S., Pinto, A., Bovin, N.A., Clemsen, J.D., Key, A.M., Rudrud, M.S., Janz, M.L., Adams, W.H., Bockholt, H.J., Burks, D.K & Shannon, K.M. (2024). Systematic review of wet biomarkers to advance clinical trials in Huntington’s disease: Methodological and training implications. Neuroscience 2024. Chicago, IL. October. |
| Rudrud, M.S., Adams, W.H., Baker, B.T., Clemsen, J.D., Key, A.M., Johnson, H., Burks, D.K. & Paulsen, J.S. (2024). Neuroimaging associations of smell deficits in prodromal Huntington’s disease. Neuroscience 2024. Chicago, IL. October. |
| Key, A.M., Bruehl, N., Minix, N., Bockholt, H.J., Geschwind, M.D. & Paulsen, J.S. (2024). Comprehensive Observational Study on the Genetic Basis of CADASIL: Insights into a Complex Neurological Disorder. American Society of Human Genetics 2024 Annual Meeting. Denver, CO. November. |
| Vander Groef, T., Burks, D.K., Minix, N. & Paulsen, J.S. (2024). Psychological effects of a predictive neurodegenerative disease diagnosis. American Society for Human Genetics 2024 Annual Meeting. Denver, CO. November. |
| Key, A.M., Pinto, A., Adams, W.H., Possin, K.L., Burks, D.K & Paulsen, J.S. (2024). Tablet-Based Cognitive Assessment Demonstrates Valid Assessment of Prodromal Huntington’s Disease. National Academy of Neuropsychology 2024 Annual Meeting. Austin, TX. November. |
| Caruso, M.R., Salloway, S., Bockholt, H.J., Burks, D.K. & Paulsen, J.S. (2024). Pregnancy Outcomes in CADASIL: Comparing Complications Between NOTCH3 Mutation Carriers and Gene Negative Biological Family Members. Paris CADASIL Meeting 2024. Paris, France. November. |
CONTACT
Clinical Science Center at the UW University Hospital, 600 Highland Ave, Madison, WI 53705
