Paulsen Lab

The Paulsen Lab

ABOUT THE LAB

The Paulsen Lab researches the early biomarkers of rare neurological disease, with a focus on Huntington’s Disease and CADASIL. The Lab conducts observational or natural history studies and investigates the clinical, imaging, biofluid, and genetic features of these diseases in order to benefit the eventual development of therapeutic interventions.

RESEARCH PROJECTS

PREVENT-HD

 

PREVENT-HD

CONTACT:

Email: hdresearch@neurology.wisc.edu
Phone: 608-890-4040

CADASIL

CADASIL Consortium

CONTACT:

Email: info@cadasil-consortium.org
Phone: 833-795-3016

TEAM

Jane Paulsen

Credentials: Ph.D.

Position title: Professor

Education

Doctorate:
University of Iowa

Post doctorate:
University of California, San Diego

Research Interests

Cognitive, psychiatric and imaging correlates of neuropsychiatric disorders; early detection of brain disease; methods development for clinical trials, genetic discrimination, discovery and validation of biological and clinical markers of brain disease; neuroimaging; omics markers as clinical trial outcomes.

Noah Bruehl

Position title: Clinical Research Coordinator I

Abigail Key

Position title: Clinical Research Coordinator I

Kerry Ludke

Position title: Clinical Research Manager

Natalie Minix

Position title: Clinical Research Coordinator I

Elizabeth Penziner

Position title: Research Program Manager

Jenna Spring

Position title: Clinical Research Coordinator I

Preparing for preventive clinical trials in Huntington's disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 7U01NS105509-03
PI: PAULSEN, JANE S
4/23/2020 - 1/31/2024
Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 7U01NS103475-04
PI: PAULSEN, JANE S
4/23/2020 - 3/31/2023
Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1RF1AG074608-01
PI: PAULSEN, JANE S
9/30/2021 - 8/31/2024
Ketchum, F.B., Chin, N.A., Grill, J., Gleason, C.E., Erickson, C., Clark, L.R., Paulsen, J.S., & Kind, A.J. (2022). Moving beyond disclosure: Stages of care in preclinical Alzheimer’s disease biomarker testing. Alzheimer’s & Dementia, 18(10), 1969-1979. doi: 10.1002/alz.12620. PMID: 35213786. PMCID: PMC9402800.
Lee, J. M., Huang, Y., Orth, M., Gillis, T., Siciliano, J., Hong, E., Mysore, J.S., Lucente, D., Wheeler, V.C., Seong, I.S., McLean, Z.L, Mills, J.A., McAllister, B., Lobanov, S.V., Massey, T.H., Ciosi, M., Landwehrmeyer, G.B., Paulsen, J.S., … & Gusella, J. (2022). Genetic modifiers of Huntington’s disease differentially influence motor and cognitive domains. The American Journal of Human Genetics, 109(5), 885-899. doi: 10.1016/j.ajhg.2022.03.004. Epub 2022 Mar 23. PMID: 35325614. PMCID: PMC9118113.
Lobanov, S.V., McAllister, B., McDade-Kumar, M., Landwehrmeyer, G.B., Orth, M., Rosser, A.E., REGISTRY Investigators of the European Huntington’s Disease Network, Paulsen, J.S., … & Jones, L. (2022). Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1. npj Genomic Medicine 7. doi: 10.1038/s41525-022-00317-w. PMID: 36064847. PMCID: PMC9445028.
Max, J.E., Troyer, E.A., Arif, H., Vaida, F., Wilde, E.A., Bigler, E.D., … & Paulsen, J.S. (2022). Traumatic brain injury in children and adolescents: psychiatric disorders 24 years later. The Journal of Neuropsychiatry and Clinical Neurosciences, 34(1), 60-67. doi: 10.1176/appi.neuropsych.20050104. Epub 2021 Sep 20. PMID: 34538075. PMCID: PMC9818773.
McAllister, B., Donaldson, J., Binda, C. S., Powell, S., Chughtai, U., Edwards, G., Stone, J., Lobanov, S., Elliston, L., Schuhmacher, L.N., Rees, E., Menzies, G., Ciosi, M., Maxwell, A., Chao, M.J., Hong, E.P., Lucente, D., Wheeler, V., Lee, J.M., MacDonald, M.E., Long, J.D., Aylward, E.H., Landwehrmeyer, G.B., Rosser, A.E., REGISTRY Investigators of the European Huntington’s disease network, Paulsen, J.S., … & Massey, T. H. (2022). Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset. Nature Neuroscience, 25(4), 446-457. doi: 10.1038/s41593-022-01033-5. Epub 2022 Apr 4. PMID: 35379994. PMCID: PMC8986535.
Eisenmenger, L.B., Peret, A., Famakin, B.M., Spahic, A., Roberts, G.S., Bockholt, H.J., … & Paulsen, J.S. (2023). Vascular Contributions to Alzheimer’s Disease. Translational Research, 254, 41-53. doi: 10.1016/j.trsl.2022.12.003. Epub 2022 Dec 15.  PMID: 36529160. PMCID: PMC10481451.
Sokol, L., Nance, M., Kluger, B.M., Yeh, C., Paulsen, J.S., Smith, A.K. & Bega, D. (2023). Factors Associated with the Place of Death in Huntington Disease: Analysis of Enroll-HD. Journal of Palliative Medicine, 26(7), 915-921. doi: 10.1089/jpm.2022.0143. Epub 2023 Jan 27. PMID: 36706436. PMCID: PMC10316529.
Sokol, L., Troost, J.P., Bega, D., Paulsen, J.S., Kluger, B.M., Applebaum, A.J., … & Carlozzi, N.E. (2023). Death Anxiety in Huntington disease: Longitudinal Health-Related Quality of Life (HRQoL) Outcomes. Journal of Palliative Medicine, 26(7), 907-914. doi: 10.1089/jpm.2022.0160. Epub 2023 Jan 6. PMID: 36607769. PMCID: PMC10316526.
Stoebner, Z.A., Hett, K., Lyu, I., Johnson, H., Paulsen, J.S., Long, J.D. & Oguz, I. (2023). Comprehensive shape analysis of the cortex in Huntington’s disease. Human Brain Mapping, 44(4), 1417-1431. doi: 10.1002/hbm.26125. Epub 2022 Nov 21. PMID: 36409662. PMCID: PMC9921229.

Oral presentations:

Paulsen, J.S. (2023). Progress in Biomarkers for Huntington’s Disease. National Academies of Science, Forum on Neuroscience and Nervous System Disorders, Multimodal Biomarkers for Central Nervous Systems Disorders, Washington, DC.
Paulsen, J.S. (2023). From gene mutation to disease prevention: Progress and challenges in the HD continuum. 148th Annual Meeting of the American Neurological Association, Philadelphia, PA.

Poster presentations:

Henson, A., Joyce, C., Pinto, A., Rudrud, M., Janz, M., Houghtaling, N., … & Paulsen, J.S. (2023). Assessing changes in irritability longitudinally in presymptomatic Huntington’s Disease gene expansion carriers. Association for Psychological Science Annual Convention. Washington, DC. May.
Houghtaling, N., Janz, M., Adams, W., Henson, A., Rudrud, M., Baumhardt, P., & Paulsen, J.S. (2023). Is the Problem Behaviors Assessment Short-form a reliable measure for Huntington’s disease? Association for Psychological Science Annual Convention. Washington, DC. May.
Pinto, A., Henson, A., Houghtaling, N., Rudrud, M., Adams, W., Possin, K., … & Paulsen, J.S. (2023). Greater Estimated Disease Burden for Huntington’s Disease Worsens Memory and Executive Functioning in Novel Cognitive Assessments. Association for Psychological Science Annual Convention. Washington, DC. May.
Rudrud, M., Adams, W., Houghtaling, N., Janz, M., Henson, A., & Paulsen, J.S. (2023). Is Olfactory Circuit Impairment Capable of Detecting Huntington’s Disease? Association for Psychological Science Annual Convention. Washington, DC. May.
Baker, B., Bockholt, H., Petropoulos, H., Calhoun, V., Caprihan, A., Paulsen, J.S., … & Newton, M. (2023). Alterations in Dynamic and Static Functional Network Connectivity in CADASIL Disease. Organization for Human Brain Mapping 2023. Montreal, QC. June.
Bockholt, H., Baker, B., Caprihan, A., Petropoulos, H., Clemsen, J., Paulsen, J.S., … & Calhoun, V. (2023). A Framework for Evaluating White Matter Hyperintensities (WMH) methods in CADASIL disease. Organization for Human Brain Mapping 2023. Montreal, QC. June.
Bockholt, H., Petropoulos, H., Caprihan, A., Paulsen, J.S., Geschwind, M., Liebeskind, D., … & Calhoun, V. (2023). Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) as a white matter disease marker in CADASIL. Organization for Human Brain Mapping 2023. Montreal, QC. June.
Baker, B.T., Bockholt, H.J., Petropoulos, H., Calhoun, V.D., Caprihan, A., Geschwind, M.D., … & Paulsen, J.S. (2023). Dynamic And Static Functional Network Connectivity Differentiates Cognitive Impairment in Individuals With CADASIL. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September.
Bhatia, A., Adams, W.H., Dono, A., Esquenazi, Y., Clemons, K.N., Dey, M., … & Paulsen, J.S. (2023). Integration of Neuroimaging, Patient-Reported Outcomes, and Genetics in IDH-mutant Gliomas. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September.
Bockholt, H.J., Adams, W.H., Geschwind, M.D., Caprihan, A., Johnson, K.M., Liebeskind, D.S., … & Paulsen, J.S. (2023). Neurovascular Imaging Markers of Cognitive Impairment in CADASIL. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September.
Bockholt, H.J., Shannon, K.M., Newton, M.A., Adams, W.H., Calhoun, V.D., & Paulsen, J.S. (2023). Remote UHDRS Motor Exam Using Machine Learning. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September.
Geschwind, M.D., Biller, J., Elliott, J.L., Jayadev, S., Salloway, S., Gutierrez, J., … & Paulsen, J.S. (2023). Unraveling the Earliest Phases of Vascular Cognitive Impairment and Dementia Using CADASIL. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September.
Geschwind, M.D., Zitser, J., Elahi, F.M., Hajjar, I., Gutierrez, J., Fathali, I., Crossland, D., Terranova, M., Driscoll, T., Bockholt, H.J., Paulsen, J.S., … & Biller, J. (2023). Retrospective Study of Multi-site CADASIL: Implications for Clinical and Research Practice. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September.
Pinto, A., Rudrud, M., Adams, W.H., Newton, M.A., Bockholt, H.J., Shannon, K.M., & Paulsen, J.S. (2023). Limitations in Biomarker Discovery Efforts for Prodromal Huntington’s Disease. 148th Annual Meeting of the American Neurological Association. Philadelphia, PA. September.

 

CONTACT

Clinical Science Center at the UW University Hospital, 600 Highland Ave, Madison, WI 53705