Our team built one of the largest studies to detect and track the earliest signs of Huntington Disease (HD). The study was called PREDICT-HD and was submitted to the NIH in 1999 by members of the Huntington Study Group. PREDICT-HD was funded by five investigator-initiated RO1 grants and sixteen collaborative UO1 grants from the NIH. CHDI also provided funds to expand the research outside of North America and develop the TRACK studies. We connected with over 1,485 participants who are at risk for HD all around the world. This Team Science included over 485 staff and faculty scientists from institutions around the world. We published over 180 peer-reviewed papers in professional journals and we have shared data, biological samples and brain imaging data to other scientists willing to help us learn more about HD. We are now starting new studies, Prevent-HD to lay the groundwork for clinical trials testing new HD therapies in at-risk participants.
More information is available at the Prevent HD web site.
| Nintendo Wii(TM) versus Xbox Kinect(TM) for functional locomotion in people with Parkinson's disease: a systematic review and network meta-analysis Marotta N, Demeco A, Indino A, de Scorpio G, Moggio L, Ammendolia A. Disabil Rehabil. 2022 Feb;44(3):331-336. doi: 10.1080/09638288.2020.1768301. Epub 2020 Jun 1. See full publication information |
| Current understandings and perspectives of petroleum hydrocarbons in Alzheimer's disease and Parkinson's disease: a global concern Rajendran R, Ragavan RP, Al-Sehemi AG, Uddin MS, Aleya L, Mathew B. Environ Sci Pollut Res Int. 2022 Feb;29(8):10928-10949. doi: 10.1007/s11356-021-17931-3. Epub 2022 Jan 9. See full publication information |
| Characterizing mild cognitive impairment in prodromal Parkinson's disease: A community-based study in China Pan C, Li Y, Ren J, Li L, Huang P, Xu P, Zhang L, Zhang W, Zhang MM, Chen J, Liu W. CNS Neurosci Ther. 2022 Feb;28(2):259-268. doi: 10.1111/cns.13766. Epub 2021 Nov 25. See full publication information |
| Current concepts in treating mild cognitive impairment in Parkinson's disease Schneider JS, Kortagere S. Neuropharmacology. 2022 Feb 1;203:108880. doi: 10.1016/j.neuropharm.2021.108880. Epub 2021 Nov 10. See full publication information |
| Subjective cognitive decline in idiopathic Parkinson´s disease: A systematic review Oedekoven C, Egeri L, Jessen F, Wagner M, Dodel R. Ageing Res Rev. 2022 Feb;74:101508. doi: 10.1016/j.arr.2021.101508. Epub 2021 Nov 3. See full publication information |
| Compensatory Mechanisms Nine Years Before Parkinson's Disease Conversion in a LRRK2 R1441H Family Sambin S, Lavisse S, Decaix C, Pyatigorskaya N, Mangone G, Valabrègue R, Arnulf I, Cormier F, Lesage S, Lehericy S, Remy P, Brice A, Corvol JC. Mov Disord. 2022 Feb;37(2):428-430. doi: 10.1002/mds.28833. Epub 2021 Oct 20. See full publication information |
| Cholinergic basal forebrain and hippocampal structure influence visuospatial memory in Parkinson's disease Berlot R, Pirtošek Z, Brezovar S, Koritnik B, Teipel SJ, Grothe MJ, Ray NJ. Brain Imaging Behav. 2022 Feb;16(1):118-129. doi: 10.1007/s11682-021-00481-0. Epub 2021 Jun 26. See full publication information |
| Greater male than female variability in regional brain structure across the lifespan Wierenga LM, Doucet GE, Dima D, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnaes D, Alpert KI, Andreassen OA, Anticevic A, Asherson P, Banaschewski T, Bargallo N, Baumeister S, Baur-Streubel R, Bertolino A, Bonvino A, Boomsma DI, Borgwardt S, Bourque J, den Braber A, Brandeis D, Breier A, Brodaty H, Brouwer RM, Buitelaar JK, Busatto GF, Calhoun VD, Canales-Rodríguez EJ, Cannon DM, Caseras X, Castellanos FX, Chaim-Avancini TM, Ching CR, Clark VP, Conrod PJ, Conzelmann A, Crivello F, Davey CG, Dickie EW, Ehrlich S, Van't Ent D, Fisher SE, Fouche JP, Franke B, Fuentes-Claramonte P, de Geus EJ, Di Giorgio A, Glahn DC, Gotlib IH, Grabe HJ, Gruber O, Gruner P, Gur RE, Gur RC, Gurholt TP, de Haan L, Haatveit B, Harrison BJ, Hartman CA, Hatton SN, Heslenfeld DJ, van den Heuvel OA, Hickie IB, Hoekstra PJ, Hohmann S, Holmes AJ, Hoogman M, Hosten N, Howells FM, Hulshoff Pol HE, Huyser C, Jahanshad N, James AC, Jiang J, Jönsson EG, Joska JA, Kalnin AJ; Karolinska Schizophrenia Project (KaSP) Consortium, Klein M, Koenders L, Kolskår KK, Krämer B, Kuntsi J, Lagopoulos J, Lazaro L, Lebedeva IS, Lee PH, Lochner C, Machielsen MW, Maingault S, Martin NG, Martínez-Zalacaín I, Mataix-Cols D, Mazoyer B, McDonald BC, McDonald C, McIntosh AM, McMahon KL, et al. Hum Brain Mapp. 2022 Jan;43(1):470-499. doi: 10.1002/hbm.25204. Epub 2020 Oct 12. See full publication information |
| A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium Gutman BA, van Erp TGM, Alpert K, Ching CRK, Isaev D, Ragothaman A, Jahanshad N, Saremi A, Zavaliangos-Petropulu A, Glahn DC, Shen L, Cong S, Alnaes D, Andreassen OA, Doan NT, Westlye LT, Kochunov P, Satterthwaite TD, Wolf DH, Huang AJ, Kessler C, Weideman A, Nguyen D, Mueller BA, Faziola L, Potkin SG, Preda A, Mathalon DH, Bustillo J, Calhoun V, Ford JM, Walton E, Ehrlich S, Ducci G, Banaj N, Piras F, Piras F, Spalletta G, Canales-Rodríguez EJ, Fuentes-Claramonte P, Pomarol-Clotet E, Radua J, Salvador R, Sarró S, Dickie EW, Voineskos A, Tordesillas-Gutiérrez D, Crespo-Facorro B, Setién-Suero E, van Son JM, Borgwardt S, Schönborn-Harrisberger F, Morris D, Donohoe G, Holleran L, Cannon D, McDonald C, Corvin A, Gill M, Filho GB, Rosa PGP, Serpa MH, Zanetti MV, Lebedeva I, Kaleda V, Tomyshev A, Crow T, James A, Cervenka S, Sellgren CM, Fatouros-Bergman H, Agartz I, Howells F, Stein DJ, Temmingh H, Uhlmann A, de Zubicaray GI, McMahon KL, Wright M, Cobia D, Csernansky JG, Thompson PM, Turner JA, Wang L. Hum Brain Mapp. 2022 Jan;43(1):352-372. doi: 10.1002/hbm.25625. Epub 2021 Sep 8. See full publication information |
| Traumatic Brain Injury in Children and Adolescents: Psychiatric Disorders 24 Years Later Max JE, Troyer EA, Arif H, Vaida F, Wilde EA, Bigler ED, Hesselink JR, Yang TT, Tymofiyeva O, Wade O, Paulsen JS. J Neuropsychiatry Clin Neurosci. 2022 Winter;34(1):60-67. doi: 10.1176/appi.neuropsych.20050104. Epub 2021 Sep 20. See full publication information |
| Preparing for preventive clinical trials in Huntington's disease Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 7U01NS105509-03 PI: PAULSEN, JANE S 4/23/2020 - 1/31/2024 |
| Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington disease Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 7U01NS103475-04 PI: PAULSEN, JANE S 4/23/2020 - 3/31/2023 |
| Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular disease Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1RF1AG074608-01 PI: PAULSEN, JANE S 9/30/2021 - 8/31/2024 |
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