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| The Juvenile Myoclonic Epilepsy Connectome Project Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1R01NS111022-01A1 PI: STRUCK, AARON F 3/15/2020 - 1/31/2026 |
| Preparing for preventive clinical trials in Huntington's disease Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 7U01NS105509-03 PI: PAULSEN, JANE S 4/23/2020 - 1/31/2025 |
| NAD+ metabolism and signaling in ALS models Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 2R01NS089640-07 PI: VARGAS, MARCELO R 9/30/2020 - 8/31/2025 |
| Electroencephalography and single-unit recordings Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1K23NS112473-01A1 PI: BOLY, MELANIE 12/15/2020 - 11/30/2025 |
| Role of FABP7 in ALS models Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1R01NS122973-01 PI: VARGAS, MARCELO R 7/1/2021 - 4/30/2026 |
| Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1RF1AG074608-01 PI: Paulsen,Jane S 09/30/2021 - 08/31/2025 |
| Brain Aging and Cognition in Epilepsy
Sponsor: UNIVERSITY OF CALIFORNIA - SAN DIEGO Award: KR 704829 PI: Jones,Jana E 09/01/2021 - 02/28/2026 |
| Preclinical Testing of the Effects of Diet and FMRP on Gut and Brain Barrier Integrity in a Mouse Model of Fragile X
Sponsor: DOD, ARMY Award: HT94252310076 PI: Westmark,Cara J 01/15/2023 - 01/14/2026 |
| Astrocyte-specific TLR4 signaling and Blood Brain Barrier permeability following acute focal cerebral ischemia Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1K08NS130144-01 PI: Famakin, Bolanle 3/1/2023 - 2/29/2028 |
| Astrocyte-specific TLR4 signaling and Blood Brain Barrier permeability following acute focal cerebral ischemia
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1K08NS130144-01 PI: Famakin,Bolanle M; 03/01/2023 - 02/29/2028 |
| Dual Orexin Antagonist Treatment to Prevent the Neurobehavioral Sequelae of TBI
Sponsor: DOD, ARMY Award: HT9425-23-1-0200 PI: Maganti,Rama Krishna 04/01/2023 - 03/31/2027 |
| Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain Injury
Sponsor: BETH ISRAEL DEACONESS MEDICAL CENTER Award: GRT65212 PI: Struck,Aaron F; 01/01/2027 - 12/31/2027 |
| Carrasco McCaul Centennial Clinicians
Sponsor: UWF - MEDICAL SCHOOL DEVELOPMENT FUND Award: 11/26/2024 PI: Carrasco Mccaul,Melisa; 07/01/2022 - 06/30/2029 |
| The Hybrid Abecedarian Approach (Hybrid AA) for Cognitive Rehabilitation of Infants Living in Wisconsin Rural Communities, Following Perinatal Brain Injuries (PBIs)
Sponsor: UWF - WISCONSIN PARTNERSHIP - MERC Award: 5129-2024 ICTR PILOT 3/18/2025 PI: Carrasco Mccaul,Melisa; 04/01/2024 - 03/31/2025 |
| Meaningful Clinical Trial Endpoints in Gliomas: A Novel Multi-modal Approach to Patients with Incurable Brain Tumors
Sponsor: UWF - WISCONSIN PARTNERSHIP - MERC Award: 6065-2024 4/22/2025 PI: Bhatia,Ankush; 07/01/2024 - 06/30/2026 |
| Neuroprotective Mechanisms underlying environmental enrichment in Alzheimer's disease
Sponsor: UWHC - AFFILIATION AGREEMENT Award: ICTR RD 18 PI: Burger,Corinna; 10/01/2024 - 09/30/2025 |
| Fabp7 silencing as a strategy to treat mutant GFAP-induced neuroinflammation in Alexander's disease
Sponsor: UWF - WISCONSIN PARTNERSHIP - MERC Award: 6847-2025 4/22/2025 PI: Vargas,Marcelo R; 11/01/2024 - 10/31/2025 |
| Pilot Study investigating the role of FAPI in glioma Sponsor: Radiology R&D/SOFIE Pharma Award: PI: Bhatia, Ankush - |
| Phase 3 Study randomizing patients to IV Berubicin vs PO Lomustine in 1st recurrent GBM Sponsor: Worldwide pharmaceuticals Award: PI: Bhatia, Ankush - |
| Phase 2 Study combining temozolomide with lomustine in MGMT Methylated GBM Sponsor: NRG Oncology (Cooperative Group) Award: PI: Bhatia, Ankush - |
| Phase 2 study combining Bevacizumab with Pulsed Reduced Dose Rate Radiotherapy in recurrent GBM Sponsor: Merck Award: PI: Bhatia, Ankush - |
| A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma Sponsor: Imvax Award: PI: Bhatia, Ankush - |
| Mapping Synaptic Density in Prodromal and Manifest Lewy Body Dementia Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1R01AG082174-01A1 PI: GALLAGHER, CATHERINE L 09/25/2024 - 07/31/2029 |
| MDA Care Center at American Family Children's Hospital
Sponsor: MUSCULAR DYSTROPHY ASSOCIATION, INC Award: 492461 PI: KWON, JENNIFER 01/01/2019 - 06/30/2025 |
| A Prospective, Long Term Registry of Patients with a Diagnosis of Spinal Muscular Atrophy
Sponsor: NOVARTIS Award: AVXS-101-RG-001 PI: KWON, JENNIFER 07/26/2018 - 12/31/2099 |
| An Open-label, Single Arm, Multi-center Extension Study Evaluating Long-term Safety, Tolerability and Effectiveness of Ofatumumab in Subjects with Relapsing Multiple Sclerosis
Sponsor: NOVARTIS Award: OMB157G2399 ATHIOS COMB PI: Luzzio,Christopher C; 08/24/2018 - 12/31/2099 |
| New-Onset Refractory Status Epilepticus (NORSE)
Sponsor: YALE UNIVERSITY Award: NORSE PI: Struck,Aaron F; 02/05/2019 - 12/31/2099 |
| A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of K0706 in Subjects With Early Parkinson's Disease
Sponsor: SUN PHARMA ADVANCED RESEARCH COMPANY LTD Award: CLR_18_06 PI: Shannon,Kathleen M; 09/11/2019 - 12/31/2040 |
| A Long-term Follow-up Study of Patients in the Clinical Trials for Spinal Muscular Atrophy Receiving AVXS-101
Sponsor: NOVARTIS Award: AVXS-101-LT-002 PI: KWON,JENNIFER 03/12/2020 - 12/31/2040 |
| A multicenter, randomized, active-controlled, double-blind, double-dummy, parallel group clinical trial, investigating the efficacy, safety, and tolerability of continuous subcutaneous ND0612 infusion in comparison to oral IR-LD/CD
Sponsor: NEURODERM LTD Award: ND0612-317 PI: Buyan Dent,Laura; 03/12/2020 - 12/31/2040 |
| Trial Of Parkinson’s And Zoledronic acid (TOPAZ)
Sponsor: PARKINSON'S FOUNDATION Award: PI: Shannon,Kathleen M; 07/09/2020 - 02/01/2026 |
| A multicenter, longitudinal, open-label, single-arm study describing cognitive processing speed changes in relapsing multiple sclerosis subjects treated with Ozanimod
Sponsor: CELGENE CORPORATION Award: RPC-1063-MS-001 PI: Frost,Natasha; 05/12/2021 - 12/31/2040 |
| Seizure Assessment and Forecasting with Efficient Rapid-EEG: A Retrospective Comparative Effectiveness Trial
Sponsor: CERIBELL Award: rapid2HELPS2B PI: Struck,Aaron F; 08/12/2021 - 12/31/2099 |
| A double blind, randomized, placebo controlled, parallel group trial of the efficacy and safety of Sativex oromucosal spray (Sativex?; nabiximols), as add on therapy in patients with spasticity due to multiple sclerosis
Sponsor: GW PHARMACEUTICALS Award: GWSP18023 PI: Luzzio,Christopher C; 10/14/2021 - 12/31/2099 |
| An Intermediate size, Expanded Access Protocol to Provide AMX0035, a Fixed Combination of Sodium Phenylbutyrate (PB) and Taurursodiol (TURSO)
Sponsor: AMYLYX PHARMACEUTICALS INC Award: AMX0035 PI: Gardon,Stephanie; 03/18/2022 - 12/31/2040 |
| Muscular Dystrophy Association Neuromuscular Observational Research (MOVR) Data Hub Protocol
Sponsor: MUSCULAR DYSTROPHY ASSOCIATION, INC Award: MOVR Registry PI: Kwon,Jennifer Meesuk; Gardon,Stephanie; 10/07/2021 - 12/31/2040 |
| Phase 3, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Apitegromab (SRK-015) in Patients with Later-Onset Spinal Muscular Atrophy
Sponsor: SCHOLAR ROCK Award: SRK-015-003 PI: Kwon,Jennifer Meesuk; 05/25/2022 - 12/31/2040 |
| ENROLL-HD A Prospective Registry Study in a Global Huntington's Disease Cohort
Sponsor: CHDI FOUNDATION Award: ENROLL-HD A-16004 PI: Shannon,Kathleen M; 03/27/2021 - 12/31/2099 |
| MDA Care Center at American Family Children's Hospital
Sponsor: MUSCULAR DYSTROPHY ASSOCIATION, INC Award: 492461 PI: Kwon,Jennifer Meesuk; 07/01/2022 - 06/30/2025 |
| Identifying the neural mechanisms of loss of consciousness during sleep using intracranial recordings in humans
Sponsor: TEMPLETON WORLD CHARITY FDN Award: TWCF-2022-30258 PI: Boly,Melanie; 01/01/2023 - 12/31/2025 |
| Accelerating research on consciousness
Sponsor: UNIVERSITEIT VAN AMSTERDAM Award: C2328.0527 TWCF0646 PI: Boly,Melanie; 03/01/2022 - 10/01/2026 |
| A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intravenous ganaxolone in status epilepticus
Sponsor: MARINUS PHARMACEUTICALS Award: 1042-SE-3003 PI: Struck,Aaron F; 06/08/2022 - 12/31/2040 |
| A Randomized, Double-Blind, Placebo-Controlled Trial of IkT-148009 in Untreated Parkinson's Disease
Sponsor: IQVIA RDS Award: IkT-148009-201 PI: Shannon,Kathleen M; 10/11/2022 - 12/31/2040 |
| Phase 3, multicenter, randomized, double-blind, group sequential, placebo-controlled study to assess efficacy and safety of rimegepant for the treatment of migraine (with or without aura) in children and adolescents ≥ 6 to < 18 years of age
Sponsor: BIOHAVEN PHARMACEUTICALS Award: BHV3000-311 PI: Zandieh,Ali; 11/28/2022 - 12/31/2099 |
| Phase 3, multicenter, open-label study to assess the long-term safety and tolerability of Rimegepant for the acute treatment of migraine (with or without aura) in children and adolescents ≥ 6 to < 18 years of age
Sponsor: BIOHAVEN PHARMACEUTICALS Award: BHV3000-312 PI: Zandieh,Ali; 01/05/2023 - 12/31/2099 |
| A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib
Sponsor: NOVARTIS PHARMACEUTICALS KK Award: LOU064C12301 PI: Frost,Natasha; 12/12/2022 - 12/31/2040 |
| Predictors of Cognitive Disability and Executive Dysfunction After Acute Symptomatic Neonatal Seizures
Sponsor: THRASHER RESEARCH FUND Award: 01841 PI: Carrasco Mccaul,Melisa; 01/01/2023 - 06/30/2025 |
| Novartis Pharmaceuticals - US - COAV101B12302, Phase IIIb, open-label, single-arm, multi-center study to evaluate the safety, tolerability and efficacy of OAV101 administered intrathecally (1.2 x 1014 vector genomes) to participants 2 to 12 years of age
Sponsor: NOVARTIS PHARMACEUTICALS KK Award: COAV101B12302 PI: Kwon,Jennifer Meesuk; 01/01/2023 - 12/31/2040 |
| A study to evaluate the effects of SAGE-718 in participants with Parkinson's Disease cognitive impairment
Sponsor: SAGE THERAPEUTICS INC Award: Sage PD 715-CNP-202 CTA PI: Shannon,Kathleen M; 05/10/2023 - 12/31/2040 |
| A Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants with Huntington's Disease
Sponsor: PAREXEL INTERNATIONAL CORPORATION Award: Sage HD 718 CTA PI: Shannon,Kathleen M; 04/21/2023 - 12/31/2040 |
| A 2-Part, Multicenter, Randomized, Blinded, Active-Controlled Phase 2 Study to Sequentially Evaluate the Safety and Efficacy of BIIB091 Monotherapy and BIIB091 Combination Therapy With Diroximel Fumarate in Participants With Relapsing Forms of MS
Sponsor: BIOGEN IDEC Award: AGR00000302 PI: Luzzio,Christopher C; 09/14/2023 - 12/31/2099 |
| Whole Genome Sequencing Study of CMT patients and their families
Sponsor: VANDA PHARMACEUTICALS INC. Award: MSN278949 PI: Kwon,Jennifer Meesuk; 11/29/2023 - 12/31/2099 |
| Development of a disease-specific clinical rating scale for the late-onset GM2 gangliosidoses (Tay-Sachs and Sandhoff) (Julie Kissell is the grad student/ PI)
Sponsor: NTL TAY-SACHS & ALLIED DISEASES ASSOC Award: MSN277277 PI: Kwon,Jennifer Meesuk; 01/04/2024 - 01/03/2026 |
| A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel, Multicenter Study to Evaluate the Safety and Efficacy of ALXN1720 in Adults with Generalized Myasthenia Gravis
Sponsor: ALEXION PHARMACEUTICALS, INC Award: ALXN1720-MG-301 PI: Gardon,Stephanie; 02/08/2024 - 12/31/2099 |
| An Open-Label, Multicenter, Extension Trial to Evaluate the Long-Term Safety and Efficacy of Apitegromab in Patients with Type 2 and Type 3 Spinal Muscular Atrophy Who Completed Previous Investigational Trials of Apitegromab
Sponsor: SCHOLAR ROCK Award: SRK-015-004 PI: Kwon,Jennifer Meesuk; 03/13/2024 - 12/31/2099 |
| Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis (DELIVER-MS)
Sponsor: CLEVELAND CLINIC FOUNDATION Award: CCF24454739 LTE DELIVER MS PI: Frost,Natasha; 07/01/2023 - 06/30/2026 |
| A Phase 2 study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and potential efficacy of multiple doses of ONO-2808 in patients with MSA
Sponsor: ONO PHARMACEUTICAL CO LTD Award: ONO-2808-03 PI: Shannon,Kathleen M; 07/03/2024 - 12/31/2099 |
| A Phase 2, Randomized, Double-blind, Sham Surgery-controlled Study of the Efficacy and Safety of Intraputaminal AAV2-GDNF in the Treatment of Adults with Moderate Stage Parkinson?s Disease
Sponsor: ASKLEPIOS BIOPHARMACEUTICAL INC Award: ASK-PD5-CS201 PI: Shannon,Kathleen M; 08/09/2024 - 12/31/2099 |
| Long-term follow-up of patients with spinal muscular atrophy treated with OAV101 IT or OAV101 IV in Clinical Trials
Sponsor: NOVARTIS PHARMACEUTICALS KK Award: OAV101A12308 3605 PI: Kwon,Jennifer Meesuk; 08/01/2024 - 08/31/2039 |
| Understanding the Role of Play Quality in Cognitive Outcomes for Children with CP-PBI
Sponsor: CAPLAN FOUNDATION FOR EARLY CHILDHOOD Award: 24-0040WI PI: Carrasco Mccaul,Melisa; 09/01/2024 - 08/31/2026 |
| The treatment of Charcot-Marie-Tooth disease, axonal, type 2S (CMT2S) in an individual patient with confirmed IGHMBP2 intronic cryptic splice variant c.1235+894C>A that is amenable to antisense oligonucleotide (ASO)-mediated correction of IGHMBP2 slicing
Sponsor: VANDA PHARMACEUTICALS INC. Award: VP-VCA-894A-2101 PI: Kwon,Jennifer Meesuk; 02/12/2025 - 12/31/2099 |
| Determining the Effectiveness of early Intensive Versus Escalation approaches for the treatment of Relapsing-Remitting Multiple Sclerosis Sponsor: CLEVELAND CLINIC FOUNDATION (PCORI prime sponsor) Award: MS-1610-37047 PI: FROST, NATASHA 2/1/2018 - 12/01/2026 |
| In vivo Imaging of Glymphatic Circulation: Measurement of Brain Interstitial Fluid Flow During Wake and Sleep with Ultra-High Performance MRI
Sponsor: GE GLOBAL RESEARCH Award: 401180352 PI: Boly,Melanie; 08/15/2022 - 08/14/2025 |
| Development of Lovastatin or Related Compounds as a Therapy for ALS
Sponsor: WASHINGTON UNIVERSITY Award: WU-24-0044 PI: Kreple,Collin John; 07/01/2023 - 06/30/2025 |
| Quantitative Ultrasound Imaging of the Neonatal Brain
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1R21HD114041-01 PI: Ikonomidou,Hrissanthi; 08/01/2024 - 07/31/2026 |
| A Mouse Model for Braak I/II Alzheimer's Pathology
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1R21AG085588-01A1 PI: Huang,Zhen; 09/15/2024 - 05/31/2026 |
| Retinal biomarkers in monogenic vascular cognitive impairment and dementia
Sponsor: DHHS, PHS, FOOD AND DRUG ADMINISTRATION Award: 1U01FD008399-01 PI: Paulsen,Jane S; 09/05/2024 - 08/31/2028 |
| A Second Intermediate-Size Expanded Access Protocol for Pridopidine in People with Amyotrophic Lateral Sclerosis
Sponsor: MASSACHUSETTS GENERAL HOSPITAL Award: AGR00005333 PI: Kreple,Collin John; 09/18/2024 - 08/31/2027 |
| Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Sponsor: MASSACHUSETTS GENERAL HOSPITAL Award: 246047 PI: Boly,Melanie; 08/01/2024 - 05/31/2025 |
| Effects of Noninvasive Brain Stimulation on the Developing Brain
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH Award: 1R21NS136909-01A1 PI: Ikonomidou,Hrissanthi; 12/15/2024 - 11/30/2026 |
