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Cregg Lab

Jared Cregg, Ph.D.

In our lab we focus on understanding brainstem circuits and their critical role in motor control. Our team employs cutting-edge techniques to dissect brainstem motor circuits in sophisticated anatomical, molecular, and functional detail. Our work aims to enhance our comprehension of the neural circuitry controlling movement, and offer insights into movement disorders such as Parkinson’s disease.  You are welcome to visit my lab’s website to see our current projects.

Basal ganglia-spinal cord pathway that commands locomotor gait asymmetries in mice.
Cregg JM, Sidhu SK, Leiras R, Kiehn O
Nat Neurosci. 2024;27(4):716-727. doi:10.1038/s41593-024-01569-8
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Highlights from the 31st Annual Meeting of the Society for the Neural Control of Movement.
Cregg JM, Mirdamadi JL, Fortunato C, Okorokova EV, Kuper C, Nayeem R, Byun AJ, Avraham C, Buonocore A, Winner TS, Mildren RL
J Neurophysiol. 2023;129(1):220-234. doi:10.1152/jn.00500.2022
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Brainstem Circuits for Locomotion.
Leiras R, Cregg JM, Kiehn O
Annu Rev Neurosci. 2022;45:63-85. doi:10.1146/annurev-neuro-082321-025137
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Brainstem neurons that command mammalian locomotor asymmetries.
Cregg JM, Leiras R, Montalant A, Wanken P, Wickersham IR, Kiehn O
Nat Neurosci. 2020;23(6):730-740. doi:10.1038/s41593-020-0633-7
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Phrenic-specific transcriptional programs shape respiratory motor output.
Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P
Elife. 2020;9:e52859. Published 2020 Jan 16. doi:10.7554/eLife.52859
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Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.
Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ
Nat Commun. 2018;9(1):3708. Published 2018 Sep 13. doi:10.1038/s41467-018-06102-7
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Phasic inhibition as a mechanism for generation of rapid respiratory rhythms.
Cregg JM, Chu KA, Dick TE, Landmesser LT, Silver J
Proc Natl Acad Sci U S A. 2017;114(48):12815-12820. doi:10.1073/pnas.1711536114
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A Latent Propriospinal Network Can Restore Diaphragm Function after High Cervical Spinal Cord Injury.
Cregg JM, Chu KA, Hager LE, Maggard RSJ, Stoltz DR, Edmond M, Alilain WJ, Philippidou P, Landmesser LT, Silver J
Cell Rep. 2017;21(3):654-665. doi:10.1016/j.celrep.2017.09.076
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Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism.
Niemi JP, DeFrancesco-Lisowitz A, Cregg JM, Howarth M, Zigmond RE
Exp Neurol. 2016;275 Pt 1(0 1):25-37. doi:10.1016/j.expneurol.2015.09.018
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Modulation of the proteoglycan receptor PTPsigma promotes recovery after spinal cord injury.
Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM, Madalena KM, Brown BP, Weng YL, Li S, Karimi-Abdolrezaee S, Busch SA, Shen Y, Silver J
Nature. 2015;518(7539):404-408. doi:10.1038/nature13974
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