Epilepsy

MISSION STATEMENT:

The Mission of the Section of Epilepsy at the University of Wisconsin School of Medicine and Public Health is to promote the health of patients with neurological disorders. We are a group of individuals with diverse interests and the common goal to maintain excellence in clinical care, education, and research.

We are committed to the teaching of medical students and residents to be future leaders in the fields of Epilepsy and  Neurology. We also aim to be the educational resource for the community and health-care providers.

The Section of Epilepsy will carry out clinical, translational and basic research in areas related to Epilepsy.

Medical Director

Aaron Struck

Credentials: M.D.

Position title: Assistant Professor

Providers

Melanie Boly

Credentials: M.D., Ph.D.

Position title: Assistant Professor

Elizabeth Felton

Credentials: M.D., Ph.D.

Position title: Assistant Professor

Smitha Holla

Credentials: M.D.

Position title: Assistant Professor

Anne Josiah

Credentials: M.D.

Position title: Assistant Professor

Robert Kotloski

Credentials: M.D., Ph.D.

Position title: Assistant Professor

Rama Maganti

Credentials: M.D.

Position title: Professor

Bradley Nix

Credentials: MD

Position title: Assistant Professor

Aaron Struck

Credentials: M.D.

Position title: Assistant Professor

Evelyn Tunnell

Credentials: M.D.

Position title: Clinical Associate Professor

APPs

Therese Aschkenase

Credentials: N.P.

Position title: Nurse Practitioner

Troy Lawrence

Credentials: N.P.

Position title: Nurse Practitioner

Defining a Proteomic Signature for Soy-Induced Metabolic Changes in Mice
Sponsor: USDA, NATL INSTITUTE FOOD & AGRICULTURE
Award: 2018-67001-28266
PI: WESTMARK, CARA J
7/15/2018 - 7/14/2023
Neuropsychological Progression in New Onset Epilepsy
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 2R56NS044351-12A1
PI: JONES, JANA E
4/1/2019 - 3/31/2022
Circadian Timekeeping, Oxidative Stress and Metabolism in ALS Models
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 7R21NS102599-03
PI: VARGAS, MARCELO R
2/15/2020 - 4/30/2022
The Juvenile Myoclonic Epilepsy Connectome Project
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R01NS111022-01A1
PI: STRUCK, AARON F
3/15/2020 - 1/31/2025
The Juvenile Myoclonic Epilepsy Connectome Project - Garcia-Ramos Admin Supplement
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R01NS111022-01A1
PI: STRUCK, AARON F
7/1/2020 - 1/31/2025
Preparing for preventive clinical trials in Huntington's disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 7U01NS105509-03
PI: PAULSEN, JANE S
4/23/2020 - 1/31/2024
Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 7U01NS103475-04
PI: PAULSEN, JANE S
4/23/2020 - 3/31/2023
NAD+ metabolism and signaling in ALS models
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 2R01NS089640-07
PI: VARGAS, MARCELO R
9/30/2020 - 8/31/2025
Electroencephalography and single-unit recordings
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1K23NS112473-01A1
PI: BOLY, MELANIE
12/15/2020 - 11/30/2025
Role of FABP7 in ALS models
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1R01NS122973-01
PI: VARGAS, MARCELO R
7/1/2021 - 4/30/2026
Testing of Their Novel Drugs in Fmr1KO Models(FXS) 
Sponsor: NEURODETECTIVE INTERNATIONAL
Award:
PI: WESTMARK, CARA J
11/1/2018 - 10/31/2021
Certified Duchenne Care Center - program support
Sponsor: PARENT PROJECT MUSCULAR DYSTROPHY
Award:
PI: KWON, JENNIFER MEESUK
1/1/2019 - 12/31/2021
DELIVER-MS
Sponsor: CLEVELAND CLINIC FOUNDATION (PCORI prime sponsor)
Award: MS-1610-37047
PI: FROST, NATASHA
2/1/2018 - 1/31/2023
Comparative Effectiveness Randomized Trial to Improve Stroke Care Delivery: C3FIT: Coordinated, Collaborative, Comprehensive, Family-based, Integrated, and Technology-enabled Care
Sponsor: VANDERBILT UNIVERSITY MEDICAL CENTER
Award: VUMC72156
PI: ADELMAN, ERIC E
2/1/2019 - 1/31/2022
Brain Aging in Persons with Childhood Onset Epilepsy: A Population Based Investigation II
Sponsor: CITIZENS UNITED FOR RESEARCH IN EPILEPSY
Award: 84626150-42313
PI: HERMANN, BRUCE P
1/1/2021 - 12/31/2021
Huntington's Disease Society of America Center of Excellence Grant
Sponsor: HUNTINGTONS DISEASE SOCIETY OF AMERICA
Award:
PI: SHANNON, KATHLEEN M
1/1/2021 - 12/31/2021
Preclinical Testing of High Fat / Low Carb Diets in Fragile X Mice and Cells
Sponsor: FRAXA RESEARCH FOUNDATION
Award:
PI: WESTMARK, CARA J
5/1/2021 - 4/30/2022
Exploring the neural basis of naming impairment in patients with epilepsy
Sponsor: AMERICAN EPILEPSY SOCIETY
Award:
PI: STRUCK, AARON F
7/1/2021 - 6/30/2022
Sleep Research Program for Advancing Careers (SOAR)
Sponsor: AMERICAN ACADEMY OF SLEEP MEDICINE FDN
Award:
PI: BAZALAKOVA, MIHAELA H
8/10/2020 - 6/16/2021
Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular disease
Sponsor: DHHS, PHS, NATIONAL INSTITUTES OF HEALTH
Award: 1RF1AG074608-01
PI: PAULSEN, JANE S
9/30/2021 - 8/31/2024
Acute Inflammation from Focal Seizures using [18F]-FEPPA PET/MR
Sponsor: Lily's Grace Grant
Award: 5/30/2019
PI: STRUCK, AARON F
07/01/2019 - 06/30/2022
Harnessing a novel Ab40 anti-inflammatory pathway for AD intervention
Sponsor: ICTR Pilot Funds
Award: ICTR-UWHC RD 14
PI: HUANG, ZHEN
09/01/2020 - 01/31/2022
Linking altered sleep homeostasis to increased autonomic instability and SUDEP risk in patients with epilepsy
Sponsor: Lily's Grace Grant
Award: 9/1/2021
PI: BOLY, MELANIE
07/01/2020 - 06/30/2022
Modeling Pathogenicity and Treatment Response in Epileptic Channelopathies
Sponsor: Lily's Grace Grant
Award: 6/4/2021
PI: KNOX, ANDREW T
07/01/2021 - 06/30/2023
Longitudinal MRI in Preclinical Parkinson Disease
Sponsor: VA
Award: I01CX000555-05A1
PI: GALLAGHER, CATHERINE L
10/1/2017 - 9/30/2022
Astrocyte-specific TLR4 signaling and Blood Brain Barrier permeability following acute focal cerebral
Sponsor: National Institutes of Health
Award: 1K08NS130144-01
PI: Famakin, Bolanle
3/1/2023 - 2/29/2024

Sponsor: CNS Pharmaceuticals
Award: CNS-201
PI: Bhatia, Ankush
23/09/2022 - 31/12/2040
ONC201 vs placebo in H3K27M-mutant diffuse midline glioma
Sponsor: Chimerix, Inc.
Award: ONC201-108
PI: Bhatia, Ankush
18/04/2023 - 31/12/2040

Sponsor: Imvax Inc.
Award: 14379-201
PI: Bhatia, Ankush
31/05/2023 - 31/12/2099
Lu177-DOTATATE in newly diagnosed and recurrent glioblastoma: Phase 1 Study
Sponsor: Novartis Pharamaceuticals KK
Award: AAA601A52101
PI: Bhatia, Ankush
01/10/2023 - 02/08/2025
Pilot Study investigating the role of FAPI in glioma
Sponsor: Radiology R&D/SOFIE Pharma
Award:
PI:
-
Phase 3 Study randomizing patients to IV Berubicin vs PO Lomustine in 1st recurrent GBM
Sponsor: Worldwide pharmaceuticals
Award:
PI: Bhatia, Ankush
-
Phase 2 Study combining temozolomide with lomustine in MGMT Methylated GBM
Sponsor: NRG Oncology (Cooperative Group)
Award:
PI: Bhatia, Ankush
-
Phase 2 study combining Bevacizumab with Pulsed Reduced Dose Rate Radiotherapy in recurrent GBM
Sponsor: Merck
Award:
PI: Bhatia, Ankush
-
A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma
Sponsor: Imvax
Award:
PI: Bhatia, Ankush
-
Sleep Deprivation Exacerbates Seizures and Diminishes GABAergic Tonic Inhibition
Konduru SS, Pan YZ, Wallace E, Pfammatter JA, Jones MV, Maganti RK.
Ann Neurol. 2021 Sep 2. doi: 10.1002/ana.26208. Online ahead of print.
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Regional and global resting-state functional MR connectivity in temporal lobe epilepsy: Results from the Epilepsy Connectome Project
Struck AF, Boly M, Hwang G, Nair V, Mathis J, Nencka A, Conant LL, DeYoe EA, Raghavan M, Prabhakaran V, Binder JR, Meyerand ME, Hermann BP.
Epilepsy Behav. 2021 Apr;117:107841. doi: 10.1016/j.yebeh.2021.107841. Epub 2021 Feb 18.
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Untangling a Web: Basic Mechanisms of the Complex Interactions Between Sleep, Circadian Rhythms, and Epilepsy
Maganti RK, Jones MV.
Epilepsy Curr. 2021 Mar;21(2):105-110. doi: 10.1177/1535759721989674. Epub 2021 Feb 5.
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Unexpected pain with electrocortical stimulation in a teenager with temporal encephalocele
Swanson LC, Hsu D, Ahmed R, Brucker J, Knox AT.
Epilepsy Behav Rep. 2021 Mar 31;16:100444. doi: 10.1016/j.ebr.2021.100444. eCollection 2021.
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Quantitative spatio-temporal characterization of epileptic spikes using high density EEG: Differences between NREM sleep and REM sleep
Kang X, Boly M, Findlay G, Jones B, Gjini K, Maganti R, Struck AF.
Sci Rep. 2020 Feb 3;10(1):1673. doi: 10.1038/s41598-020-58612-4.
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Validation of an algorithm of time-dependent electro-clinical risk stratification for electrographic seizures (TERSE) in critically ill patients
Cissé FA, Osman GM, Legros B, Depondt C, Hirsch LJ, Struck AF, Gaspard N.
Clin Neurophysiol. 2020 Aug;131(8):1956-1961. doi: 10.1016/j.clinph.2020.05.031. Epub 2020 Jun 23.
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Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER.
Neuron. 2020 Jul 8;107(1):52-64.e7. doi: 10.1016/j.neuron.2020.04.003. Epub 2020 May 1.
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Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity
Rivera Bonet CN, Hwang G, Hermann B, Struck AF, J Cook C, A Nair V, Mathis J, Allen L, Almane DN, Arkush K, Birn R, Conant LL, DeYoe EA, Felton E, Maganti R, Nencka A, Raghavan M, Shah U, Sosa VN, Ustine C, Prabhakaran V, Binder JR, Meyerand ME.
Epilepsy Behav. 2020 Sep;110:107172. doi: 10.1016/j.yebeh.2020.107172. Epub 2020 Jun 14.
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The Johns Hopkins Neurosciences Intensive Care Nursery Tenth Anniversary (2009-2019): A Historical Reflection and Vision for the Future
Carrasco M, Stafstrom CE, Tekes A, Parkinson C, Northington FJ; Johns Hopkins Neurosciences Intensive Care Nursery.
Child Neurol Open. 2020 Mar 17;7:2329048X20907761. doi: 10.1177/2329048X20907761. eCollection 2020 Jan-Dec.
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Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy
Hermann B, Conant LL, Cook CJ, Hwang G, Garcia-Ramos C, Dabbs K, Nair VA, Mathis J, Bonet CNR, Allen L, Almane DN, Arkush K, Birn R, DeYoe EA, Felton E, Maganti R, Nencka A, Raghavan M, Shah U, Sosa VN, Struck AF, Ustine C, Reyes A, Kaestner E, McDonald C, Prabhakaran V, Binder JR, Meyerand ME.
Neuroimage Clin. 2020;27:102341. doi: 10.1016/j.nicl.2020.102341. Epub 2020 Jul 10.
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